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24 Jun 2011 03:24 | |
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I\'m not sure why you would be telling people this. For a variety of reasons these statements are not factual and could have serious consequences for members if they follow. There are classes of pathogens including staph, strep, and other gram negative organisms that macrophages are not effective in surpressing. In addition there have been studies presented that show PMMA infections including this one presented on the old site aestheticfacialenhancement.co.za/faq/49-...injections.html\"One patient presented with infection (hyperemia, edema, and pustule formation 1 year after injection).\" PMMA is great stuff and Dr C is the best in the world at putting it in a penis but lets not get carried away. There is a reason he perscribes ABs! |
24 Jun 2011 03:24 | |
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I\'ve taken this excerpt from one of the reports about migration: Migration Studies and Histology of Injectable Microspheres of Different Sizes in Mice Gottfried Lemperle, M.D., Ph.D., Vera B. Morhenn, M.D., Vasumati Pestonjamasp, Ph.D., and Richard L. Gallo, M.D., Ph.D. San Diego, Calif. Injectable dermal filler materials consist of either fluids, biological fragments, or suspensions of particles or microspheres. Particles and microspheres are said to 'migrate,' but migration can occur only when they are injected into blood vessels. To evaluate biocompatibility and transport, five nonresorbable polymethylmethacrylate microspheres of various sizes, suspended in different carriers, as well as resorbable polylactic acid and dextran microspheres were injected subcutaneously into mice. The five implantation sites were the right cheek, right axilla, right groin, urethra, and the right quadriceps muscle of the thigh. These sites were excised along with the local lymph nodes, lungs, liver, and spleen at 1, 3, 6, and 9 months after injection. Polymethylmethacrylate microspheres of 4 m and 8 m were phagocytosed but not transported to lymph nodes or distant organs. Larger microspheres of 20, 40, and 100 m were encapsulated by connective tissue, macrophages, and giant cells. Polylactic acid microspheres caused a mild inflammatory response and had disappeared at 6 months. Dextran microspheres caused a pronounced foreign-body reaction and were phagocytosed at 9 months. The extremely large carboncoated spheres of 200 to 500 m in diameter 'migrated' up to 1 cmfrom the implantation site. With the exception of an erroneous intravenous injection, no migration or transportation of any of the injected microspheres to lymph nodes or filter organs was seen. Obviously, the collagen glue released no microspheres. After subdermal injection, the collagen carrier substance kept the microspheres apart as a scaffold for tissue ingrowth, whereas all other carrier substances, such as gelatin, hyaluronic acid, or alginate, separated soon after injection, thereby causing agglomeration of the microspheres. (Plast. Reconstr. Surg. 113: 1380, 2004.) |