@hung,
\" I would be very concerned about the use of this product for PE. I fear over the long haul you can expect the collagen to harden and eventually break down the tertiary tissue leading to necrosis. Hopefully a good plastic surgeon could save the penis.. Time will tell...but as for me FFT seems the best route. I wish you all the best and the girth augmenation is real but I really am terrified for long term consequences such as absorbtion(auto-immune) and migration(testicles). \"
I understand your fear about the long-term consequences of pmma in our body, but we know the following points about pmma:-
1- It is used in human for more than 50 years ( Intra-ocular lenses in 1949 for cataract, for artificial joints and bone cement in spine ) without causing biological degradation or cancer and the pmma did not change in its composition.
2- It is used for more than 20 years as a tissue augmentation by Lemperle in europe.
This is an old article of Lemperle in 1991 for the worst PMMA generation \"ArtePlast\" in rats where he used the small beads 10 microns which he found later on that was the reason why he got 2.5% FBG in this product beside its irregular surface and its electro-static charges :-
www.ncbi.nlm.nih.gov/pubmed/1994814
3- It had the FDA approval in 2006 .
Wouldn\'t be these 3 points enough in regard of long term complications of PMMA ??
In summary:- pmma is used for > 50 years in our body, so if there was one case of long term complication wouldn\'t we read about it ?? Would the FDA give the approval for this product to be injected in the face if there was a chance of ( hardening the collagen or break down the tissues surrounding it or absorption or migration) ??
N.B. we are talking only about the product per se (PMMA in general) and its late complications and not the technique of the doctor or the site of injection.
I think the only long term issues I will be more concerned are aesthetic looks (lumps and nodules) and Foreign Body Granulomas (6 months-5 years).